![]() Approximately 20-25% of a single dose of nitrofurantoin is recovered from the urine unchanged over 24 hours. Based on urinary pharmacokinetic data, the extent and rate of urinary excretion of nitrofurantoin from the 100 mg Nitrofurantoin Capsules, USP (monohydrate/ macrocrystals) are similar to those of the 50 mg or 100 mg nitrofurantoin (macrocrystals). The remaining 75% is nitrofurantoin monohydrate contained in a powder blend which, upon exposure to gastric and intestinal fluids, forms a gel matrix that releases nitrofurantoin over time. Twenty-five percent is macrocrystalline nitrofurantoin, which has slower dissolution and absorption than nitrofurantoin monohydrate. CLINICAL PHARMACOLOGYĮach Nitrofurantoin Capsules, USP (monohydrate/ macrocrystals) contains two forms of nitrofurantoin. 10, FD&C Red No.40, gelatin, titanium dioxide, lactose, magnesium stearate, povidone, talc, sodium lauryl sulfate, colloidal silicon dioxide and Opacode® black ink S-1-17843 (consist of shellac, ferrosoferric oxide, butyl alcohol, propylene glycol, isopropyl alcohol and ammonia).įDA approved dissolution test specifications differ from USP. Inactive Ingredients: Each capsule contains carbomer 974P, pregelatinized starch, sucrose, FD&C Blue No.1, FD&C Yellow No.
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